Rnf144b
WebMore importantly, we found that PIR2/Rnf144b binds and mediates proteasomal degradation of ΔNp63α, generating a hitherto unknown auto-regulatory feedback loop. These findings substantiate PIR2/Rnf144b as a potentially critical component of epithelial homeostasis, acting downstream of ΔNp63α to regulate cellular levels of p21 (WAF1/CIP1) and ... WebTarget Information. E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent …
Rnf144b
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WebAug 15, 2016 · For the overexpression of RNF144B, the RNF144B gene sequence was synonymously mutated at two nucleotides (underlined) to avoid recognition by RNF144B-siRNA. β-tubulin was used as a control. WebPrimePCR™ Template for SYBR® Green Assay: Rnf144b, Rat Reaction: 4 billion copies/200 µl desalted Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding primer assay.
WebThe gene view histogram is a graphical view of mutations across RNF144B. These mutations are displayed at the amino acid level across the full length of the gene by … WebJan 4, 2005 · Function. E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent …
WebJul 1, 2024 · RNF144B is an E3 ubiquitin ligase that recognizes target genes for ubiquitination. RNF144B is amplified and over expressed (RNAseq) in 16% of HGSOCs (n=316, TCGA). RNF144B is expressed as a 35kDA protein in both normal (ovary and fallopian tube) and ovarian cancer cell lines. WebSample Description FPKM; TCGA-B5-A1MU-01A: 79 years, female, white, dead, 1548 days: 117.9: TCGA-DI-A1NO-01A: 68 years, female, black or african american, dead, 285 ...
WebMar 21, 2024 · GeneCards Summary for RNF144A Gene. RNF144A (Ring Finger Protein 144A) is a Protein Coding gene. Among its related pathways are Protein ubiquitination …
WebRNF144B INFORMATION. Proteini. Full gene name according to HGNC. Ring finger protein 144B. Gene namei. Official gene symbol, which is typically a short form of the gene name, … flesh eating illnessWebPR:000014088 E3 ubiquitin-protein ligase RNF144B (term hierarchy) EC. 2.3.2.31. InterPro Domains. IPR031127 E3 ubiquitin ligase RBR family. IPR002867 IBR domain. IPR044066 TRIAD supradomain. IPR013083 Zinc finger, RING/FYVE/PHD-type. IPR001841 Zinc finger, RING-type. IPR017907 Zinc finger, RING-type, conserved site. Molecular Reagents chekc if a parent has a child apexWebJan 27, 2016 · In addition to RNF144B, 3 other genes (SLC41A2, NKG7, and G0S2) that were LPS regulated in HMDMs were silenced as specificity controls. siRNA-mediated gene knockdown in primary human macrophages followed by qPCR analysis confirmed the specificity of the siRNAs used (Supplemental Fig. 1) and revealed that RNF144B … chek cifWebJun 16, 2014 · Although RNF144A also shares high homology sequence with RNF144B in amino acids 173–252, we did not observe a strong interaction between RNF144B and DNA-PKcs (Fig. 3B). This observation might be because of a different subcellular localization or protein orientation on the plasma membrane between RNF144A and RNF144B or other … chekc if number exists in array phpchekchecking for updatesWebRNF144B ring finger protein 144B. E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then … chekc iconWebNg et al. (2003) cloned human RNF144B, which they called p53RFP, from a U373MG human glioblastoma cell line cDNA library. The putative 303-amino acid protein contains a RING … chekchov three sisters synopsis