Intrastrand adducts
WebPlatinum chemotherapeutic agents have been widely used in the treatment of cancer. Cisplatin was the first of the platinum-based chemotherapeutic agents and therefore has been extensively studied as an antitumor agent since the late 1960s. Because this agent forms several DNA adducts, a highly sensitive and specific quantitative assay is needed … WebSep 11, 1997 · The anticancer platinum compound cis-Pt(NH3)2Cl2 (cisplatin) forms covalent cross-linked adducts with DNA, with the intrastrand didentate adduct between …
Intrastrand adducts
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WebMar 19, 2014 · Firstly, they are able to alter the tertiary structure of DNA by forming intrastrand adducts and interstrand crosslinks. 62 Moreover, it has been documented … WebMay 26, 2009 · Because trans-diamminedichloroplatinum(ii) is incapable of forming 1,2-intrastrand cross-links on DNA, 32, 33 and because this complex has insignificant antitumor activity in cells, 34 intrastrand adducts are more likely to be responsible for the cytotoxicity of cisplatin in cancer cells.
WebAbstract. Cisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked … Webintrastrand cross linking DNA adducts. The cisplatin derived 1,2 guanine-guanine intrastrand [CP-d(GpG)]1 cross links are the most prevalent, compromising ∼65% of the …
WebAug 11, 2024 · Our findings that a recently identified Rev1 inhibitor, JH-RE-06, purported to specifically disrupt Rev1 interaction with Polζ to block TLS through cisplatin adducts in … WebMay 8, 2009 · In contrast, the cytotoxic-inactive complex 2 preferentially forms 1,4-intrastrand rather than 1,3-intra- and -interstrand cross-links. Digestion of the DNA adducts of 1 shows that the cleavage is completely blocked at one nucleotide before the cross-linked guanine residues on the opposite strand, a feature that appears to be unprecedented in …
WebFormation of interstrand and intrastrand crosslinks by the covalent binding of both PBD moieties of the dimer to the exocyclic 2-amino group of the two guanine bases within the …
gayelette the wonderful wizard of ozWebApr 7, 2024 · Several types of oxidatively generated DNA lesions were suggested as candidates. In the first line, these include intrastrand crosslinks, such as 5′,8-cyclopurine-2 ... Due to the presence of the covalent 5′,8 bonds (Figure 1A), cyclo-dA and cyclo-dG adducts are intrinsically resistant to excision by DNA N-glycosylases ... day of meatWebMay 25, 2016 · It is thought that DNA intrastrand adducts at GG sequences are the significant sites of cisplatin’s biological effectiveness and anti-tumour activity [11, 12]. … day of meat armor gamesWebFeb 20, 2015 · Cisplatin can bind on DNA molecules in 1,2-intrastrand and interstrand modes [2], [3], [4]. Recent studies demonstrated that 1,2-intrastrand cross-links were the most important configurations for cytotoxicity [1]. The major intrastrand adducts are the 1,2-intrastrand cross-links at the d(GpG) and d(ApG) sites [5]. day of meat gameWebInterstrand and intrastrand adducts were formed with duplexes both longer and shorter than the preferred target sequences. ELB-21 elicited rapid bactericidal effects against … day of meat radiation pokiWebDec 19, 2024 · One possible explanation is the formation of long-range intra- or interstrand crosslinks between two nucleobases that are distant in the DNA primary structure but are … day of meat hacksWebX-Ray structural investigation of Pt–DNA adducts initially focused on platinated di- or trinucleotides. 36–38 However, it was not until a platinated DNA dodecamer duplex … day of mathematics